TC-E 5007

Name: TC-E 5007
Brand: Tocris Bioscience
SKU: 5204
Rating: 5 (2 reviews)

Cat. No. 5204 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5204 has been discontinued.

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说明： Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor

别名： allo-I1e-isoindoline

化学名： (2S,3R)-2-Amino-1-(1,3-dihydro-2_H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for TC-E 5007

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC₅₀ values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.

技术数据 for TC-E 5007

分子量	268.78
公式	C₁₄H₂₀N₂O.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
PubChem ID	91826083
InChI Key	WKUCMHGVDQUBMQ-HTKOBJQYSA-N
Smiles	CC[C@@H](C)[C@H](N)C(N1CC(C=CC=C2)=C2C1)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for TC-E 5007

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TC-E 5007

参考文献是支持产品生物活性的出版物。

Lankas et al (2005) Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 54 2988 PMID: 16186403

Wu et al (2009) Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem.Pharmacol. 78 203 PMID: 19439267

Van der Veken et al (2007) Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. J.Med.Chem. 50 5568 PMID: 17958345

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关键词: TC-E 5007, TC-E 5007 supplier, TC-E5007, 956039079, 956039_07_9, irreversible, selective, dipeptidyl, peptidases, DPP-8, DPP-9, inhibitors, inhibits, allo-I1e-isoindoline, Other, Proteases, 5204, Tocris Bioscience

篇 TC-E 5007 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 TC-E 5007 的引用文献。

TC-E 5007 的评论

平均评分: 5 (基于 2 条评论。)

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TC-E 5007 inhibits CaMKII phosphorylation in cardiomyocytes.

By Christopher Trummer on 10/22/2018

分析类型： In Vitro

种属： Mouse

细胞系/组织： cardiomyocytes

HL-1 cardiomyocytes were treated with TC-E 5007 (1 µM) for 0-60 min and CaMKII phosphorylation was assessed using Western blot.

TC-E 5007 impairs Ca2+ transient relaxation.

By Chintan Koyani on 10/13/2018