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说明： Positive allosteric modulator of NPY Y4 receptor
化学名： 2-[4-(1,1-Dimethylethyl)phenoxy]cyclohexanol
纯度： ≥98% (HPLC)
生物活性 for tBPC
tBPC is a positive allosteric modulator of neuropeptide Y receptor 4 (Y4R). Potentiates Y4R response to pancreatic polypeptide (PP), neuropeptide Y (NPY) and peptide YY (PYY) (EC50 values are 0.03, 0.4 and 0.5 nM respectively). Shows selectivity for Y4R over Y1R, Y2R and Y5R.
技术数据 for tBPC
| 分子量 | 248.36 |
| 公式 | C16H24O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1942-71-8 |
| PubChem ID | 16033 |
| InChI Key | FTIXUILRMBSXNS-UHFFFAOYSA-N |
| Smiles | CC(C)(C1=CC=C(C=C1)OC2CCCCC2O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for tBPC
参考文献 for tBPC
参考文献是支持产品生物活性的出版物。
Schubert et al (2017) Identification and characterization of the first selective Y4 receptor positive allosteric modulator. J.Med.Chem. 60 7605 PMID: 28795803
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关键词: tBPC, tBPC supplier, Neuropeptide, Y, receptor, 4, NPY, Y4R, positive, allosteric, modulators, modulates, PAM, Receptors, 6411, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.