Talabostat mesylate

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Cat.No. 3719 - Talabostat mesylate | C9H19BN2O3.CH3SO3H | CAS No. 150080-09-4
说明: Potent DPP IV inhibitor; activates NLRP1b inflammasome
别名: Val-boroPro, BXCL 701
化学名: B-[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid methanesulfonate
纯度: ≥98% (HPLC)
说明书
引用文献
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生物活性 for Talabostat mesylate

Talabostat mesylate is a potent DPP IV inhibitor (IC50 values are <4, 4, 11, 310 and 560 nM at DPP4, DPP8, DPP9, DPP7 and FAP, respectively). Activates the inflammasome sensor protein NLRP1b and selectively triggers pyroptosis in monocytes and macrophages. Induces immune-mediated tumor regression in multiple mouse models of cancer. Orally bioavailable.

技术数据 for Talabostat mesylate

分子量 310.18
公式 C9H19BN2O3.CH3SO3H
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 150080-09-4
PubChem ID 11522448
InChI Key OXYYOEIGQRXGPI-WSZWBAFRSA-N
Smiles O=C([C@@H](N)C(C)C)N1CCC[C@H]1B(O)O.CS(O)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Talabostat mesylate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 31.02 100
DMSO 31.02 100

制备储备液 for Talabostat mesylate

以下数据基于产品分子量 310.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.12 mL 32.24 mL
5 mM 0.64 mL 3.22 mL 6.45 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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产品说明书 for Talabostat mesylate

参考文献 for Talabostat mesylate

参考文献是支持产品生物活性的出版物。

Okondo et al (2017) DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat.Chem.Biol. 13 46 PMID: 27820798

Okondo et al (2018) Inhibition of Dpp8/9 activates the Nlrp1b inflammasome. Cell Chem.Biol. 25 262 PMID: 29396289


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关键词: Talabostat mesylate, Talabostat mesylate supplier, Potent, DPP, IV, inhibitors, inhibits, inflammasome, pyroptosis, Nlrp1b, BXCL701, DPP4, Val-boroPro, BXCL, 701, Dipeptidyl, Peptidase, (DPP-IV), Inflammasomes, 3719, Tocris Bioscience

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