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SR 3029

Cat. No. 5767 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5767 has been discontinued.

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说明： Potent and selective CK1δ and CK1ε inhibitor
化学名： N-((6,7-Difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for SR 3029

SR 3029 is a potent and selective CK1δ and CK1ε inhibitor (IC50 values are 44 and 260 nM, respectively). Exhibits selectivity for CK1δ and CK1ε over a panel of other kinases. Inhibits proliferation of melanoma and breast cancer cell lines in vitro. Also inhibits growth of breast tumor xenografts in mice.

技术数据 for SR 3029

分子量 480.45
公式 C23H19F3N8O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1454585-06-8
PubChem ID 60196195
InChI Key CEBMEQPREMCWOL-UHFFFAOYSA-N
Smiles FC1=C(F)C2=C(N=C(CNC3=C4C(N(C5=CC=CC(F)=C5)C=N4)=NC(N6CCOCC6)=N3)N2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SR 3029

参考文献是支持产品生物活性的出版物。

Bibian et al (2013) Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg.Med.Chem.Lett. 23 4374 PMID: 23787102

Rosenberg et al (2015) Therapeutic targeting of casein kinase 1δ in breast cancer. Sci.Transl.Med. 7 318 PMID: 26676609

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关键词: SR 3029, SR 3029 supplier, SR3029, CK1d, CK1e, δ, delta, ε, epsilon, casein, kinase, inhibitors, inhibits, potent, selective, Casein, Kinase, 1, 5767, Tocris Bioscience

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