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Submit ReviewSF 1670
说明： PTPN2 and PTEN inhibitor
别名： PTP Inhibitor XIX
化学名： N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide
纯度： ≥98% (HPLC)
生物活性 for SF 1670
SF 1670 is a PTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.
技术数据 for SF 1670
| 分子量 | 307.34 |
| 公式 | C19H17NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 345630-40-2 |
| PubChem ID | 9926586 |
| InChI Key | VZQDDSYKVYARDW-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC=C1C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SF 1670
参考文献 for SF 1670
参考文献是支持产品生物活性的出版物。
Li (2011) Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117 6702 PMID: 21521784
Le et al (2017) Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor. BMB Rep. 50 329 PMID: 28228214
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关键词: SF 1670, SF 1670 supplier, SF1670, PTEN, inhibitors, phosphatase, tensin, homolog, deleted, chromosome, 10, neutrophils, transfusion, inhibits, PTPN2, CD45, cancer, immunotherapy, PTP, Inhibitor, XIX, Protein, Tyrosine, Phosphatases, 5020, Tocris Bioscience
2 篇 SF 1670 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SF 1670 的部分引用包括：
Gail A et al (2022) TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22. Sci Signal 15 eabn5507 PMID: 36166512
Lei et al (2017) Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity. J Cell Biol 216 2551 PMID: 28659327
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