SB 743921 hydrochloride

Cat. No. 5109 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent kinesin spindle protein (KSP) inhibitor

化学名： N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SB 743921 hydrochloride

SB 743921 hydrochloride is a potent kinesin spindle protein (KSP) inhibitor (K_i = 0.1 nM). Induces cell mitotic arrest and apoptosis in vitro. Inhibits the growth of a range of tumor cells in vitro, including colon (HCT 116), prostate (PC-3) and leukemia (K-562) cancer cell lines. Causes tumor regression in human tumor xenograft models in vivo, including colon (Colo205), lung (H69) and breast (MCF7) cancer cell xenografts.

许可信息

Sold with the permission of GlaxoSmithKline.

技术数据 for SB 743921 hydrochloride

分子量	553.52
公式	C₃₁H₃₃ClN₂O₃.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	940929-33-9
PubChem ID	49867937
InChI Key	MLMZVWABFOLFGV-LNLSOMNWSA-N
Smiles	ClC1=CC=C2C(OC([C@@H]([C@H](C)C)N(C(C4=CC=C(C)C=C4)=O)CCCN)=C(CC3=CC=CC=C3)C2=O)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 743921 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	55.35	100

制备储备液 for SB 743921 hydrochloride

以下数据基于产品分子量 553.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.03 mL	18.07 mL
5 mM	0.36 mL	1.81 mL	3.61 mL
10 mM	0.18 mL	0.9 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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产品说明书 for SB 743921 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SB 743921 hydrochloride

参考文献是支持产品生物活性的出版物。

Jackson et al (2006) A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer. First AACR International Conference on Molecular and Diagnostics in Cancer Therapeutic Development. Abstract (B11)

Good et al (2013) Optimized S-trityl-_L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J.Med.Chem. 56 1878 PMID: 23394180

Talapatra et al (2013) Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism. J.Med.Chem. 56 6317 PMID: 23875972

If you know of a relevant reference for SB 743921 hydrochloride, please let us know.

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