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Submit ReviewRVG29-Cys 最新
说明： Nicotinic acetylcholine receptor targeting peptide for neuronal delivery
纯度： ≥95% (HPLC)
生物活性 for RVG29-Cys
RVG29-Cys is a peptide derived from rabies virus glycoprotein (RVG) able to specifically bind on the nicotinic acetylcholine receptors (nAchR) present on neuronal cells. RVG29-Cys can be used to functionalize LNPs via thiol-maleimide click chemistry for targeting nAchR present on blood-brain barrier (BBB). mRNA LNPs functionalized with RVG29-Cys shows improved transfection efficiency in cultured brain endothelial and neuronal cells, and in vivo, after systemic administration in mice.
技术数据 for RVG29-Cys
| 分子量 | 3369.79 |
| 公式 | C144H222N44O44S3 |
| 序列 | YTIWMPENPRPGTPCDIFTNSRGKRASNGC |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1404289-25-3 |
| PubChem ID | 172898615 |
| InChI Key | SQWGWNJDPJYWQQ-FMHCIDBQSA-N |
| Smiles | O=C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCSC)C(N3[C@@H](CCC3)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(NCC(N[C@@H]([C@H](O)C)C(N6[C@@H](CCC6)C(N[C@@H](CS)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC8=CC=C(C=C8)O)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for RVG29-Cys
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for RVG29-Cys
参考文献 for RVG29-Cys
参考文献是支持产品生物活性的出版物。
Han et al (2025) Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain. Nano Lett. 25 800 PMID: 39688915
Liu et al (2009) Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles. Biomaterials 30 4195 PMID: 19467700
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关键词: RVG29-Cys, RVG29-Cys supplier, RVG29, RVG29Cys, RVG, Lipid, nanoparticles, LNP, mRNA, peptides, brain, tissue, delivery, blood-brain, barrier, BBB, neurons, endocytosis, transcytosis, in, vivo, Nanoparticles, Endocytosis, 8903, Tocris Bioscience
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