RS 17053 hydrochloride

Name: RS 17053 hydrochloride
Brand: Tocris Bioscience
SKU: 0985

Cat. No. 0985 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0985 has been discontinued.

View all Adrenergic α<sub>1</sub> Receptors products.

说明： α_1A antagonist

化学名： (N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine) hydrochloride

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for RS 17053 hydrochloride

RS 17053 hydrochloride is an α_1A-adrenoceptor antagonist, with very high affinity for α_1A receptors (pK_i and pA₂ estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α_1B and α_1D subtypes (pK_i and pA₂ estimates 7.7 - 7.8).

许可信息

Sold with the permission of Roche Bioscience

技术数据 for RS 17053 hydrochloride

分子量	449.42
公式	C₂₄H₂₉N₂O₂Cl.HCl
储存	Store at RT
CAS Number	169505-93-5
PubChem ID	9824953
InChI Key	QFOPFGRPNPCPBX-UHFFFAOYSA-N
Smiles	Cl.CC(C)(CC1=CNC2=CC=C(Cl)C=C12)NCCOC1=C(OCC2CC2)C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RS 17053 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RS 17053 hydrochloride

参考文献是支持产品生物活性的出版物。

Ford et al (1996) RS 17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine hydrochloride, a selective α1A-adrenoceptor antagonist, displays low affinity for functional α1-adrenoceptors in huma Mol.Pharmacol. 49 209 PMID: 8632751

Marshall et al (1996) Different subtypes of α_1A-adrenoceptor mediating contraction of rat epididymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonist RS 17053. Br.J.Pharmacol. 119 407 PMID: 8886428

Ford et al (1995) Do α_1A (α_1C)-adrenoceptors (AR) mediate prostatic smooth muscle contraction in man? Studies with a novel, selective α_1A-AR antagonist, RS 17053. Br.J.Pharmacol. 114 C25

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篇 RS 17053 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 RS 17053 hydrochloride 的引用文献。