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Submit ReviewRo 32-3555
说明： Potent, collagenase-selective MMP inhibitor
化学名： (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide
纯度： ≥97% (HPLC)
生物活性 for Ro 32-3555
Potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.
技术数据 for Ro 32-3555
| 分子量 | 436.55 |
| 公式 | C22H36N4O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 190648-49-8 |
| PubChem ID | 9824350 |
| InChI Key | GFUITADOEPNRML-SJORKVTESA-N |
| Smiles | O=[C@@](N3CCCCC3)[C@H](CC1CCCC1)[C@@H]([C@](NO)=O)CN2C(N(C)C(C)(C)C2=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ro 32-3555
参考文献 for Ro 32-3555
参考文献是支持产品生物活性的出版物。
Lewis et al (1997) Ro 32-3555, an orally active Col. inhibitor, prevents cartilage breakdown in vitro and in vivo. Br.J.Pharmacol. 121 540 PMID: 9179398
Broadhurst et al (1997) Design and synthesis of the cartilage protective agent (CPA, Ro32-3555). Bioorg.Med.Chem.Letts. 7 2299
Brewster et al (1998) Ro 32-3555, an orally active Col. selective inhibitor, prevents structural damage in the SRT/ORT mouse model of osteoarthritis. Arthrit.Rheumat. 41 1639
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关键词: Ro 32-3555, Ro 32-3555 supplier, Ro32-3555, MMP, matrix, metalloproteinase, metalloprotease, collagenase, potent, specific, selective, MMP-1, MMP-13, MMP-8, proteases, proteineases, Matrix, Metalloprotease, 2916, Tocris Bioscience
2 篇 Ro 32-3555 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ro 32-3555 的部分引用包括：
Brilha (2017) Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis. Sci Rep 7 16031 PMID: 29167512
Przybyla et al (2013) Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells 31 1097 PMID: 23404867
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