(R)-CE3F4

Name: (R)-CE3F4
Brand: Tocris Bioscience
SKU: 5969

Cat. No. 5969 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5969 has been discontinued.

View all EPAC products.

说明： Epac inhibitor; R-enantiomer of CE3F4 (Cat. No. 4793)

化学名： (2R)-5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for (R)-CE3F4

(R)-CE3F4 is an Epac inhibitor (IC₅₀ values are 4.2 and 44 μM for Epac1 and Epac2(B), respectively). Blocks activation of Epac by cAMP. This is the R-enantiomer of CE3F4 (Cat.No.4793).

许可信息

Sold for research use only under license from Inserm, Université Toulouse III - Paul Sabatier, Université Paris-Sud and Université d′Orléans.

技术数据 for (R)-CE3F4

分子量	351.01
公式	C₁₁H₁₀Br₂FNO
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1593478-56-8
PubChem ID	73669655
InChI Key	ZZLQPWXVZCPUGC-ZCFIWIBFSA-N
Smiles	BrC1=C(F)C(Br)=C(CC[C@@H](C)N2C=O)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (R)-CE3F4

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (R)-CE3F4

参考文献是支持产品生物活性的出版物。

Courilleau et al (2013) The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem.Biophys.Res.Commun. 440 443 PMID: 24099776

Boulton et al (2018) Mechanism of selective enzyme inhibition through uncompetitive regulation of an allosteric agonist. J.Am.Chem.Soc. 140 9624 PMID: 30016089

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关键词: (R)-CE3F4, (R)-CE3F4 supplier, Epac, antagonists, antagonism, R-enantiomer, cAMP, Rap1, guanine-nucleotide, exhange, factor, GEF, RAPGEF3, EPAC, 5969, Tocris Bioscience

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