Pomalidomide 4'-alkylC4-acid

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Cat.No. 7209 - Pomalidomide 4'-alkylC4-acid | C18H19N3O6 | CAS No. 2225940-48-5
说明: Cereblon ligand with alkyl linker and terminal acid for onward chemistry
化学名: 5-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentanoic acid
纯度: ≥95% (HPLC)
文献 (2)

生物活性 for Pomalidomide 4'-alkylC4-acid

Pomalidomide 4'-alkylC4-acid is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC4 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for Pomalidomide 4'-alkylC4-acid

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for Pomalidomide 4'-alkylC4-acid

分子量 373.37
公式 C18H19N3O6
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2225940-48-5
PubChem ID 139331580
Smiles OC(CCCCNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pomalidomide 4'-alkylC4-acid

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 37.34 100
DMF 37.34 100

制备储备液 for Pomalidomide 4'-alkylC4-acid

以下数据基于产品分子量 373.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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产品说明书 for Pomalidomide 4'-alkylC4-acid

参考文献 for Pomalidomide 4'-alkylC4-acid


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关键词: Pomalidomide 4'-alkylC4-acid, Pomalidomide 4'-alkylC4-acid supplier, PROTAC, component, cereblon, E3, ubiquitin, ligase, AlkylC4, linker, conjugate, building, block, ligands, targeted, targeting, protein, degradation, TPD, Cereblon, Ligands, Plus, Linkers, 7209, Tocris Bioscience

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