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说明： P2Y ligand; displays mixed antagonism/potentiation
别名： 2,2'-Pyridylisatogen tosylate
化学名： 2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate
纯度： ≥99% (HPLC)
生物活性 for PIT
PIT is a purinergic P2Y receptor ligand. Displays irreversible antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y1 receptor and sympathetic/purinergic nerve stimulation).
技术数据 for PIT
| 分子量 | 396.42 |
| 公式 | C13H8N2O2.C7H8O3S |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 56583-49-4 |
| PubChem ID | 124333 |
| InChI Key | MMPTYEXNPWSTOR-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(C=C1)S(O)(=O)=O.[O-][N+]1=C(C(=O)C2=CC=CC=C12)C1=CC=CC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PIT
参考文献 for PIT
参考文献是支持产品生物活性的出版物。
King et al (1996) Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. Br.J.Pharmacol. 117 1111 PMID: 8882604
Ren and Burnstock (1997) Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2.2'-pyridylisatogen tosylate. Br.J.Pharmacol. 120 530 PMID: 9031760
Spedding et al (1975) Antagonism of adenosine 5'-triphosphate-induced relaxation by 2-2'-pyridylisatogen in the taenia of guinea-pig caecum. Br.J.Pharmacol. 53 575 PMID: 1148500
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关键词: PIT, PIT supplier, P2Y, ligands, displays, mixed, antagonism/potentiation, Receptors, Purinergic, antagonists, potentiators, purinoceptors, 2,2'-Pyridylisatogen, tosylate, 1682, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.