Olopatadine hydrochloride

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Cat.No. 4241 - Olopatadine hydrochloride | C21H23NO3.HCl | CAS No. 140462-76-6
说明: H1 antagonist; ocular antiallergic agent
化学名: (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride
纯度: ≥99% (HPLC)
文献 (3)

生物活性 for Olopatadine hydrochloride

Olopatadine hydrochloride is a histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

化合物库 for Olopatadine hydrochloride

Olopatadine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Olopatadine hydrochloride

分子量 373.87
公式 C21H23NO3.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 140462-76-6
PubChem ID 5282402
Smiles O=C(CC(C=C3)=CC/1=C3OCC(C=CC=C2)=C2C1=C\CCN(C)C)O.Cl


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Olopatadine hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
water 28.04 75
DMSO 37.39 100

制备储备液 for Olopatadine hydrochloride

以下数据基于产品分子量 373.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.37 mL 26.75 mL
5 mM 0.53 mL 2.67 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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产品说明书 for Olopatadine hydrochloride

参考文献 for Olopatadine hydrochloride


Tamura et al (2007) Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 81 118 PMID: 17962722

Sharif et al (1996) Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharm.Exp.Ther. 278 1252

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查看全部 Histamine H1 Receptor Antagonists

关键词: Olopatadine hydrochloride, Olopatadine hydrochloride supplier, histamine, H1, antagonists, antihistamines, mast, cell, stabilizers, ocular, antiallergic, Histamine, Receptors, 4241, Tocris Bioscience

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