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Submit ReviewNS 6740
Discontinued Product
6139 has been discontinued.
说明： High affinity α7 nAChR partial agonist; anti-inflammatory
化学名： 1,4-Diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride
纯度： ≥98% (HPLC)
生物活性 for NS 6740
NS 6740 is a high affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.
技术数据 for NS 6740
| 分子量 | 400.82 |
| 公式 | C19H19F3N2O2.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 753499-14-8 |
| PubChem ID | 68676769 |
| InChI Key | QHSRBONTAYCFCC-UHFFFAOYSA-N |
| Smiles | O=C(N1CCN2CCC1CC2)C(O3)=CC=C3C4=CC(C(F)(F)F)=CC=C4.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NS 6740
参考文献 for NS 6740
参考文献是支持产品生物活性的出版物。
Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID: 19845675
Thomsen et al (2012) The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia. J.Neuroimmunol. 251 65 PMID: 22884467
Papke et al (2015) The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor. Neuropharmacology 91 34 PMID: 25497451
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关键词: NS 6740, NS 6740 supplier, NS6740, alpha7, a7, nicotinics, acetylcholine, receptors, partial, agonists, agonism, silent, anti-inflammatory, high, affinity, Nicotinic, (a7), Receptors, 6139, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.