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Submit ReviewNS 383
说明： ASIC blocker; active in vivo
化学名： 8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
生物活性 for NS 383
NS 383 is an ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
技术数据 for NS 383
| 分子量 | 321.37 |
| 公式 | C19H19N3O2 |
| 储存 | Store at -20°C |
| CAS Number | 309711-59-9 |
| PubChem ID | 135418391 |
| InChI Key | CHVQAXYXYIDNDC-UHFFFAOYSA-N |
| Smiles | CCN1CCC2=C(C3=C(/C(C(N3)=O)=N\O)C=C2C4=CC=CC=C4)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NS 383
参考文献 for NS 383
参考文献是支持产品生物活性的出版物。
Munro et al (2016) NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 22 135 PMID: 26663905
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关键词: NS 383, NS 383 supplier, NS383, ASIC, blockers, acid-sensing, ion, channels, inflammatory, pain, Voltage-gated, Sodium, Channels, 5927, Tocris Bioscience
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