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Submit ReviewML 351
说明： Selective 12/15 LOX inhibitor; active in vivo
化学名： 5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile
纯度： ≥98% (HPLC)
生物活性 for ML 351
ML 351 is a selective 12/15 LOX inhibitor (IC50 = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.
化合物库 for ML 351
ML 351 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for ML 351
| 分子量 | 249.27 |
| 公式 | C15H11N3O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 847163-28-4 |
| PubChem ID | 664510 |
| InChI Key | DYXYXTDIFMDJIR-UHFFFAOYSA-N |
| Smiles | CNC1=C(C#N)N=C(C2=CC=CC3=C2C=CC=C3)O1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ML 351
参考文献 for ML 351
参考文献是支持产品生物活性的出版物。
Rai et al (2014) Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J.Med.Chem. 57 4035 PMID: 24684213
Rai et al (2014) Discovery of ML351, a potent and selective inhibitor of human 15-lipoxygenase-1. Probe Reports from the NIH Molecular Libraries Program PMID: 24672829
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关键词: ML 351, ML 351 supplier, ML351, Selective, 12/15-lipoxygenase, inhibitors, inhibits, 12/15, LOX, Lipoxygenase, 6448, Tocris Bioscience
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