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说明： Pyruvate kinase M2 activator
化学名： 4,6-Dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
纯度： ≥98% (HPLC)
生物活性 for ML 202
Potent activator of pyruvate kinase M2 (PKM2) (IC50 = 73 nM). Exhibits little or no activity against the pyruvate kinase isozymes PKM1, PKL and PKR.
技术数据 for ML 202
| 分子量 | 387.48 |
| 公式 | C18H17N3O3S2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1221186-52-2 |
| PubChem ID | 44246498 |
| InChI Key | MORBXZMIXGYQDB-UHFFFAOYSA-N |
| Smiles | O=C1N(CC4=CC=CC(OC)=C4)N=CC2=C1N(C)C3=C2SC(S(C)=O)=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ML 202
参考文献 for ML 202
参考文献是支持产品生物活性的出版物。
Boxer et al (2010) Identification of activators for the M2 isoform of human pyruvate kinase version 3. Probe Reports from the Molecular Libraries Program PMID: 21735594
Jiang et al (2010) Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg.Med.Chem.Lett. 20 3387 PMID: 20451379
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关键词: ML 202, ML 202 supplier, ML202, PKM2, pyruvate, kinases, activators, potent, Other, Kinases, 4859, Tocris Bioscience
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