KYA 1797K

Pricing Availability   Qty
Cat.No. 7002 - KYA 1797K | C17H11KN2O6S2 | CAS No. 1956356-56-1
说明: Wnt/β-catenin signaling inhibitor
化学名: (5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
纯度: ≥98% (HPLC)
文献 (1)
通路 (1)

生物活性 for KYA 1797K

KYA 1797K is a Wnt/β-catenin signaling inhibitor (IC50 = 0.75 μM). Increases binding affinity of β-catenin for axin, GSK-3β and β-TrCP. Promotes formation of the destruction complex, activation of GSK-3β and phosphorylation of β-catenin and K-Ras, leading to their degradation via the ubiquitin/proteasome system. Reduces levels of β-catenin and K-Ras and inhibits growth of colorectal cancer (CRC) cells in vitro and in mouse xenograft models.

技术数据 for KYA 1797K

分子量 442.5
公式 C17H11KN2O6S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1956356-56-1
PubChem ID 119057297
Smiles C1=CC(=CC=C1C2=CC=C(O2)/C=C\3/C(=O)N(C(=S)S3)CCC(=O)[O-])[N+](=O)[O-].[K+]


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溶解性数据 for KYA 1797K

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 2.21 5 温和加热

制备储备液 for KYA 1797K

以下数据基于产品分子量 442.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 45.2 mL 225.99 mL 451.98 mL
0.25 mM 9.04 mL 45.2 mL 90.4 mL
0.5 mM 4.52 mL 22.6 mL 45.2 mL
2.5 mM 0.9 mL 4.52 mL 9.04 mL

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参考文献 for KYA 1797K


Cha et al (2016) Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat.Chem.Biol. 12 593 PMID: 27294323

Park et al (2019) A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer. Sci.Rep. 9 648 PMID: 30679620

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关键词: KYA 1797K, KYA 1797K supplier, KYA1797K, wnt, beta, catenin, β, signaling, pathway, inhibitors, inhibits, K-Ras, destruction, complex, promotes, Beta-catenin, 7002, Tocris Bioscience

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for KYA 1797K

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.