Jingzhaotoxin III

Pricing Availability   Qty
Cat.No. 4913 - Jingzhaotoxin III | Asp-Gly-Glu-Cys-Gly-Gly-Phe-Trp-Trp-Lys-Cys-Gly-Arg-Gly-Lys-Pro-Pro-Cys-Cys-Lys-Gly-Tyr-Ala-Cys-Ser-Lys-Thr-Trp-Gly-Trp-Cys-Ala-Val-Glu-Ala-Pro (Disulfide bridges: 4-19, 11-24, 18-31) | CAS No. 925463-91-8
说明: Selective NaV1.5 channel blocker
纯度: ≥95% (HPLC)
说明书
引用文献
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文献 (5)

生物活性 for Jingzhaotoxin III

Jingzhaotoxin III is a selective blocker of NaV1.5 channels (IC50 = 348 nM); displays no effect on other isoforms, including NaV1.2, NaV1.4, NaV1.6 and NaV1.7. Thought to inhibit sodium channel activation by binding to the NaV1.5 S3-S4 linker of domain II. Selectively inhibits the activation of cardiac sodium channels, but has no effect on sodium channels in dorsal root ganglion neurons.

技术数据 for Jingzhaotoxin III

分子量 3919.5
公式 C174H241N47O46S6
序列 DGECGGFWWKCGRGKPPCCKGYACSKTWGWCAVEAP

(Modifications: Disulfide bridges: 4-19, 11-24, 18-31)

储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 925463-91-8
PubChem ID 90488988
InChI Key OKELXNUZHJLTAQ-UHFFFAOYSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)CNC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)CNC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)CNC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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溶解性数据 for Jingzhaotoxin III

溶解性 Soluble to 1 mg/ml in water

产品说明书 for Jingzhaotoxin III

分析证书/产品说明书
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参考文献 for Jingzhaotoxin III

参考文献是支持产品生物活性的出版物。

Xiao et al (2004) Jingzhaotoxin-III, a novel spider toxin inhibiting activation of sodium channel in rat cardiac myocytes. J.Biol.Chem. 279 26220 PMID: 15084603

Rong et al (2011) Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5. FASEB J. 25 3177 PMID: 21665957


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关键词: Jingzhaotoxin III, Jingzhaotoxin III supplier, cardiotoxins, NaV1.5, selective, ion, channels, sodium, blockers, blocks, inhibitors, inhibits, venoms, Voltage-gated, Sodium, Channels, 4913, Tocris Bioscience

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