INCA-6

Name: INCA-6
Brand: Tocris Bioscience
SKU: 2162

Cat. No. 2162 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2162 has been discontinued.

View all Protein Ser/Thr Phosphatases products.

说明： Inhibitor of calcineurin-substrate association

化学名： 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione

纯度： ≥95% (HPLC)

说明书

引用文献 (3)

生物活性技术数据说明书参考文献

生物活性 for INCA-6

INCA-6 is an inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (K_d = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

技术数据 for INCA-6

分子量	284.31
公式	C₂₀H₁₂O₂
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	3519-82-2
PubChem ID	230748
InChI Key	GCHPUOHXXCNSQL-UHFFFAOYSA-N
Smiles	O=C1C=CC(=O)C2=C1C1C3=C(C=CC=C3)C2C2=C1C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for INCA-6

分析证书/产品说明书

化学品安全技术说明书

参考文献 for INCA-6

参考文献是支持产品生物活性的出版物。

Roehrl et al (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci.USA 101 7554