You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
生物活性 for Homoharringtonine
Homoharringtonine is an inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic. Inhibits SARS-CoV-2 infection in vitro (IC50 = 2.55 μM).
技术数据 for Homoharringtonine
|储存||Store at RT|
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Homoharringtonine
|溶剂||最高浓度 mg/mL||最高浓度 mM|
制备储备液 for Homoharringtonine
以下数据基于产品分子量 545.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|浓度/溶剂体积/质量||1 mg||5 mg||10 mg|
|1 mM||1.83 mL||9.16 mL||18.33 mL|
|5 mM||0.37 mL||1.83 mL||3.67 mL|
|10 mM||0.18 mL||0.92 mL||1.83 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
参考文献 for Homoharringtonine
Cai et al (2001) Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia 15 567 PMID: 11368358
Fresno et al (1977) Inhibition of translation in eukaryotic systems by harringtonine. Eur.J.Biochem. 72 323 PMID: 319998
Zhou et al (1995) Homoharringtonine: an effective new natural product in cancer chemotherapy. Bull.Cancer 82 987 PMID: 8745664
Choy et al (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 178 PMID: 32251767
If you know of a relevant reference for Homoharringtonine, please let us know.
关键词: Homoharringtonine, Homoharringtonine supplier, inhibitors, inhibits, protein, synthesis, Antileukemic, agent, DNA,, RNA, and, Protein, Synthesis, Coronavirus, 1416, Tocris Bioscience
3 篇 Homoharringtonine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Homoharringtonine 的部分引用包括：
Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638 PMID: 23792643
Paige et al (2019) AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo. Neurobiol Pain 5 PMID: 31080914
Akef et al (2015) Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements. Cell J 21 1908 PMID: 26362019
您是否知道使用了 Tocris Homoharringtonine 的优秀论文？ 请告知我们.
平均评分: 5 (Based on 1 Review.)
Have you used Homoharringtonine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
Cell Cycle and DNA Damage Research Product GuideNew
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Huntington's Disease Research Product GuideNew
This product guide provides a background to Huntington's disease and includes research tools for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Stem Cells
- Regenerative Medicine