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Cat.No. 1416 - Homoharringtonine | C29H39NO9 | CAS No. 26833-87-4
说明: Inhibitor of protein synthesis; antileukemic agent
化学名: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
纯度: ≥98% (HPLC)
引用文献 (3)
评论 (1)
文献 (3)

生物活性 for Homoharringtonine

Homoharringtonine is an inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic. Inhibits SARS-CoV-2 infection in vitro (IC50 = 2.55 μM).

技术数据 for Homoharringtonine

分子量 545.63
公式 C29H39NO9
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 26833-87-4
PubChem ID 285033
Smiles O=C([C@](CCCC(O)(C)C)(O)CC(OC)=O)O[C@@H]1C(OC)=C[C@@](N(CCC5)CCC2=CC4=C(OCO4)C=C23)5[C@]31[H]


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溶解性数据 for Homoharringtonine

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 100
ethanol 50

制备储备液 for Homoharringtonine

以下数据基于产品分子量 545.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.16 mL 18.33 mL
5 mM 0.37 mL 1.83 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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产品说明书 for Homoharringtonine


参考文献 for Homoharringtonine


Cai et al (2001) Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia 15 567 PMID: 11368358

Fresno et al (1977) Inhibition of translation in eukaryotic systems by harringtonine. Eur.J.Biochem. 72 323 PMID: 319998

Zhou et al (1995) Homoharringtonine: an effective new natural product in cancer chemotherapy. Bull.Cancer 82 987 PMID: 8745664

Choy et al (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 178 PMID: 32251767

If you know of a relevant reference for Homoharringtonine, please let us know.


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关键词: Homoharringtonine, Homoharringtonine supplier, inhibitors, inhibits, protein, synthesis, Antileukemic, agent, DNA,, RNA, and, Protein, Synthesis, Coronavirus, 1416, Tocris Bioscience

3 篇 Homoharringtonine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Homoharringtonine 的部分引用包括:

Xia et al (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 14 638 PMID: 23792643

Paige et al (2019) AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo. Neurobiol Pain 5 PMID: 31080914

Akef et al (2015) Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements. Cell J 21 1908 PMID: 26362019

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Homoharringtonine completely kills melanoma cell line at micromolar concentrations.
By Anonymous on 02/07/2019
分析类型: In Vitro
种属: Human
细胞系/组织: SK-MEL-28

Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).

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