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GSK 923295A

Cat. No. 6837 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor
化学名： 3-Chloro-N-[(1S)-2-[[2-(dimethylamino)acetyl]amino]-1-[[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethyl]-4-(1-methylethoxy)benzamide
纯度： ≥97% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for GSK 923295A

GSK 923295A is a potent and selective centromere associated protein E (CENP-E) allosteric inhibitor (IC50 = 22 nM); does not compete with ATP. Exhibits selectivity over a panel of other kinesins (<25% inhibition at 50 μM). Inhibits tumor cell growth in vitro. Induces mitotic arrest and regression of human tumor xenografts in vivo.

技术数据 for GSK 923295A

分子量 592.13
公式 C32H38ClN5O4
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 1088965-37-0
PubChem ID 46898058
InChI Key WHMXDBPHBVLYRC-OFVILXPXSA-N
Smiles CC(OC1=C(C=C(C(N[C@@H](CC2=CC=C(C3=CN4C=CC=C(C4=N3)[C@@H](O)C)C=C2)CNC(CN(C)C)=O)=O)C=C1)Cl)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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参考文献 for GSK 923295A

参考文献是支持产品生物活性的出版物。

Qian et al (2010) Discovery of the first potent and selective inhibitor of centromere-associated protein E: GSK923295. ACS Med.Chem.Lett. 1 30 PMID: 24900171

Wood et al (2010) Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc.Natl.Acad.Sci.U.S.A. 107 5839 PMID: 20167803

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关键词: GSK 923295A, GSK 923295A supplier, GSK923295A, ATPase, Potent, selective, centromere, associated, protein, E, CENP-E, allosteric, inhibitors, inhibits, mitotic, kinesin, mitosis, Kinesin, 6837, Tocris Bioscience

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