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Cat.No. 4795 - Galloflavin | C12H5O8K | CAS No. 1780260-20-9
说明: Lactate dehydrogenase inhibitor; impairs aerobic glycolysis
化学名: 3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione potassium salt
纯度: ≥95% (HPLC)
引用文献 (1)
评论 (1)
文献 (1)

生物活性 for Galloflavin

Galloflavin is an inhibitor of human lactate dehydrogenase (LDH) (Ki values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate). Inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells; thought to decrease cell viability via impairment of aerobic glycolysis.

技术数据 for Galloflavin

分子量 316.26
公式 C12H5O8K
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 1780260-20-9
PubChem ID 90488971
Smiles [K+].OC1=C(O)C(O)=C2C3=C(OC(=O)C2=C1)C=C([O-])C(=O)O3


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溶解性数据 for Galloflavin

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 1.58 5

制备储备液 for Galloflavin

以下数据基于产品分子量 316.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 63.24 mL 316.2 mL 632.39 mL
0.25 mM 12.65 mL 63.24 mL 126.48 mL
0.5 mM 6.32 mL 31.62 mL 63.24 mL
2.5 mM 1.26 mL 6.32 mL 12.65 mL

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产品说明书 for Galloflavin


参考文献 for Galloflavin


Manerba et al (2012) Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem 7 311 PMID: 22052811

Fiume et al (2013) Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells. Biochem.Biophys.Res.Commun. 430 466 PMID: 23237800

Farabegoli et al (2012) Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur.J.Pharm.Sci. 47 729 PMID: 22954722

If you know of a relevant reference for Galloflavin, please let us know.



查看全部 Lactate Dehydrogenase A Inhibitors

关键词: Galloflavin, Galloflavin supplier, lactate, dehydrogenases, LDH-A, LDH-B, LDH, inhibitors, inhibits, aerobic, glycolysis, Lactate, Dehydrogenase, A, 4795, Tocris Bioscience

1 篇 Galloflavin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Galloflavin 的部分引用包括:

Kottakis et al (2016) LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 390 PMID: 27799657

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Galloflavin 的评论

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We got expected effect on cells.
By Anonymous on 04/03/2020
分析类型: In Vitro
种属: Mouse
细胞系/组织: Primary pancreatic ductal epithelial cells

20 μM galloflavin

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