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DMAT

Cat. No. 3686 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3686 has been discontinued.

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说明： Cell-permeable inhibitor of CK2; also inhibits Pim kinase and PKD1
化学名： 2-(Dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidazole
纯度： ≥99% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for DMAT

High affinity, cell-permeable inhibitor of casein kinase 2 (CK2) (Ki = 40 nM; IC50 = 0.13 μM). Displays no activity at CK1 at concentrations up to 200 μM. Also inhibits Pim kinase (IC50 values are 0.097, 0.148 and 1.6 μM for Pim-3, Pim-1 and Pim-2 kinase respectively), and protein kinase D1 (IC50 = 0.18 μM). Derivative of TBB (Cat.No. 2275).

技术数据 for DMAT

分子量 476.79
公式 C9H7Br4N3
储存 Store at +4°C
纯度 ≥99% (HPLC)
Smiles BrC1=C(Br)C(Br)=C(NC(N(C)C)=N2)C2=C1Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for DMAT

参考文献是支持产品生物活性的出版物。

Inglis et al (2008) Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J.Biol.Chem. 284 2598 PMID: 19004816

Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353 PMID: 18588507

Pagano et al (2004) 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2. Biochem.Biophys.Res.Comm. 321 1040

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关键词: DMAT, DMAT supplier, cell-permeable, kinase, inhibitors, inhibits, casein, 2, CK2, pim, pim1, pim2, pim3, protein, d1, pkd1, Casein, Kinase, Pim, Protein, D, 3686, Tocris Bioscience

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