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Damnacanthal

Cat. No. 1936 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1936 has been discontinued.

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说明： Potent, selective p56lck inhibitor; also LIMK1/2 inhibitor
化学名： 9,10-Dihydroxy-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Damnacanthal

Damnacanthal is a potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Mobilizes intracellular Ca2+ in dermal fibroblasts and inhibits Ras function. Also inhibits LIMK1/2, as well as migration and invasion of breast cancer cells in vitro.

技术数据 for Damnacanthal

分子量 282.25
公式 C16H10O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 477-84-9
PubChem ID 2948
InChI Key IPDMWUNUULAXLU-UHFFFAOYSA-N
Smiles O=C2C3=C(C=C(O)C(C=O)=C3OC)C(C1=CC=CC=C12)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Damnacanthal

参考文献是支持产品生物活性的出版物。

Hiramatsu et al (1993) Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia. Cancer Lett. 73 161 PMID: 7693328

Faltynek et al (1995) Damnacanthal is a highly potent, selective inhibitor fo p56lck tyrosine kinase activity. Biochemistry 34 12404 PMID: 7547985

Aoki et al (2000) Mechanism of damnacanthal-induced [Ca2+]i elevation in human dermal fibroblasts. Eur.J.Pharmacol. 387 119 PMID: 10650151

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关键词: Damnacanthal, Damnacanthal supplier, potent, inhibitors, inhibits, p56lck, kinases, selective, Src, Kinases, LIMK, 1936, Tocris Bioscience

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