Pricing Availability   Qty
Cat.No. 1364 - Colchicine | C22H25NO6 | CAS No. 64-86-8
说明: Inhibitor of tubulin
化学名: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
纯度: ≥98% (HPLC)
引用文献 (5)
评论 (1)
文献 (3)

生物活性 for Colchicine

Colchicine is a plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. Identified as a candidate for repurposing for COVID-19. Inhibits NLRP3 inflammasomes. Also decreases TNF-α receptor expression and reduces cytokine levels in macrophages. Anti-inflammatory.

技术数据 for Colchicine

分子量 399.44
公式 C22H25NO6
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 64-86-8
PubChem ID 2833
Smiles COC1=C(OC)C(OC)=C2C(CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Colchicine

溶剂 最高浓度 mg/mL 最高浓度 mM
water 39.94 100
DMSO 39.94 100

制备储备液 for Colchicine

以下数据基于产品分子量 399.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.52 mL 25.04 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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产品说明书 for Colchicine


参考文献 for Colchicine


Bai et al (1996) Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colch. J.Biol.Chem. 271 12639 PMID: 8647876

Burns (1992) Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 297 205 PMID: 1544399

Hastie (1991) Interactions of colch. with tubulin. Pharmacol.Ther. 51 377 PMID: 1792241

Morselli et al (2021) Network medicine framework for identifying drug repurposing opportunities for COVID-19. Proc.Nat.Acad.Sci.U.S.A. 118 PMID: 33906951

Ribeiro et al (2020) The therapeutic potential of colch in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? Metabol.Open 7 100045 PMID: 32808940

Martinez et al (2018) The NLRP3 inflammasome and the emerging role of colch to inhibit atherosclerosis-associated inflammation. Atherosclerosis 269 262 PMID: 29352570

If you know of a relevant reference for Colchicine, please let us know.

关键词: Colchicine, Colchicine supplier, inhibitors, inhibits, tubulin, Tau, Tubulin, Microtubules, Mitosis, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, inflammasome, NLRP3, Inflammasomes, 1364, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Colchicine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to

5 篇 Colchicine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Colchicine 的部分引用包括:

Melemedjian et al (2014) Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Mol Pain 10 45 PMID: 24993495

Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007

Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202

Khan et al (2016) Genetic screening reveals a link between Wnt signaling and antitubulin drugs. Pharmacogenomics J 16 164 PMID: 26149735

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Colchicine 的评论

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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma.
By Anonymous on 11/17/2019
分析类型: In Vitro
种属: Human
细胞系/组织: Human epidermal carcinoma cell line

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007
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