Calcineurin Autoinhibitory Peptide

Name: Calcineurin Autoinhibitory Peptide
Brand: Tocris Bioscience
SKU: 1891

Cat. No. 1891 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1891 has been discontinued.

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说明： Selective calcineurin inhibitor

别名： Autoinhibitory peptide 457-482

说明书

引用文献 (3)

生物活性技术数据说明书参考文献

生物活性 for Calcineurin Autoinhibitory Peptide

Calcineurin Autoinhibitory Peptide is a selective inhibitor of Ca²⁺-calmodulin-dependent protein phosphatase (calcineurin) (IC₅₀ ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC₅₀ > 100 mM).

技术数据 for Calcineurin Autoinhibitory Peptide

分子量	2930.34
公式	C₁₂₄H₂₀₅N₃₉O₃₉S₂
序列	ITSFEEAKGLDRINERMPPRRDAMP
储存	Desiccate at -20°C
CAS Number	148067-21-4
PubChem ID	90488720
InChI Key	JRQDGUSHUYLSHC-TVQDNDAUSA-N
Smiles	[H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Calcineurin Autoinhibitory Peptide

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参考文献 for Calcineurin Autoinhibitory Peptide

参考文献是支持产品生物活性的出版物。

Hashimoto et al (1990) Identification of an autoinhibitory domain in calcineurin. J.Biol.Chem. 265 1924 PMID: 2153670

Perrino et al (1995) Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. J.Biol.Chem. 270 340 PMID: 7814394

Yokoyama and Wang (1994) The role of the autoinhibitory domain in differential metal ion activation of calmodulin-stimulated phosphatase. FEBS Lett. 337 128 PMID: 8287965

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关键词: Calcineurin autoinhibitory peptide, Calcineurin autoinhibitory peptide supplier, Selective, calcineurin, inhibitors, inhibits, Protein, Ser/Thr, Phosphatases, Autoinhibitory, peptide, 457-482, NFAT, 1891, Tocris Bioscience

3 篇 Calcineurin Autoinhibitory Peptide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Calcineurin Autoinhibitory Peptide 的部分引用包括：

Rashki et al (2019) Cyclosporin A attenuating MOR tolerance through inhibiting NO/ERK signaling pathway in human glioblastoma cell line: the involvement of calcineurin. EXCLI J 17 1137 PMID: 30713473

Krenz et al (2015) Tonic 5nM DA stabilizes neuronal output by enabling bidirectional activity-dependent regulation of the hyperpolarization activated current via PKA and calcineurin. PLoS One 10 e0117965 PMID: 25692473

Biou et al (2008) Endocytosis and recycling of AMPA receptors lacking GluR2/3. J Pharmacol Exp Ther 105 1038 PMID: 18195348