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Submit ReviewBigLEN (rat)
说明： Potent GPR171 agonist
生物活性 for BigLEN (rat)
Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.
技术数据 for BigLEN (rat)
| 分子量 | 1746 |
| 公式 | C76H128N24O23 |
| 序列 | LENSSPQAPARRLLPP |
| 储存 | Store at -20°C |
| CAS Number | 369377-66-2 |
| PubChem ID | 131648251 |
| InChI Key | IPOOBASOJFKEAK-GTJGPZIJSA-N |
| Smiles | [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BigLEN (rat)
参考文献 for BigLEN (rat)
参考文献是支持产品生物活性的出版物。
Gomes et al (2013) GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc.Natl.Acad.Sci.USA. 110 16211 PMID: 24043826
Mack et al (2019) Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation. ACS Chem.Neurosci. 10 1884 PMID: 30726666
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关键词: BigLEN (rat), BigLEN (rat) supplier, agonists, agonism, GPR171, body, weight, neurite, outgrowth, 6306, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
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Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.