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AZD 9291

Cat. No. 8873 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent mutant-selective EGFR inhibitor
化学名： N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZD 9291

AZD 9291 is a potent mutant-selective EGFR inhibitor (IC50 values are 1 and 12 nM against EGFR mutants L858R/T790M and L858R, respectively). AZD 9291 exhibited nearly 200 times greater potency against L858R/T790M than wild-type EGFR. In vivo, AZD 9291 causes tumor regression in mutant EGFR xenograft models of non-small cell lung cancer (NSCLC) and transgenic mutant T790M EGFR disease models. AZD 9291 is orally bioavailable.

技术数据 for AZD 9291

分子量 499.61
公式 C28H33N7O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1421373-65-0
PubChem ID 71496458
InChI Key DUYJMQONPNNFPI-UHFFFAOYSA-N
Smiles O=C(C=C)NC1=CC(NC=2N=CC=C(N2)C3=CN(C=4C=CC=CC34)C)=C(OC)C=C1N(C)CCN(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZD 9291

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.98 50
ethanol 9.99 20

制备储备液 for AZD 9291

以下数据基于产品分子量 499.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4 mL 20.02 mL 40.03 mL
2.5 mM 0.8 mL 4 mL 8.01 mL
5 mM 0.4 mL 2 mL 4 mL
25 mM 0.08 mL 0.4 mL 0.8 mL

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参考文献 for AZD 9291

参考文献是支持产品生物活性的出版物。

Cross et al (2014) AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 4 1046 PMID: 24893891

If you know of a relevant reference for AZD 9291, please let us know.

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关键词: AZD 9291, AZD 9291 supplier, AZD9291, AZD-9291, osimertinib, potent, mutant-selective, EGFR, epidermal, growth, factor, receptor, tyrosine, kinase, inhibitors, inhibits, lung, cancer, T790M, L858R, non-small, cell, nsclc, orally, bioavailable, 8873, Tocris Bioscience

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