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Submit ReviewAlda 1
说明： ALDH2 activator; cardioprotective
化学名： N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
纯度： ≥98% (HPLC)
生物活性 for Alda 1
Alda 1 is an activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.
化合物库 for Alda 1
Alda 1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Alda 1
| 分子量 | 324.16 |
| 公式 | C15H11Cl2NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 349438-38-6 |
| PubChem ID | 831629 |
| InChI Key | NMKJFZCBCIUYHI-UHFFFAOYSA-N |
| Smiles | O=C(C3=C(Cl)C=CC=C3Cl)NCC1=CC(OCO2)=C2C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Alda 1
参考文献 for Alda 1
参考文献是支持产品生物活性的出版物。
Chen et al (2008) An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart. Science 321 1493 PMID: 18787169
Beretta et al (2010) Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitrogly. and effects of alda-1. J.Biol.Chem. 285 943 PMID: 19906643
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关键词: Alda 1, Alda 1 supplier, aldehyde, dehydrogenases, activators, aldh2, aldh2*1, aldh2*2, aldh22, aldh21, cardiac, ischemia, Alda1, Aldehyde, Dehydrogenase, 4005, Tocris Bioscience
2 篇 Alda 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Alda 1 的部分引用包括：
Ling et al (2021) Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice. Alcohol Clin Exp Res 45 1950-1964 PMID: 34486131
Tao et al (2020) Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study. BMC Ophthalmol 20 55 PMID: 32070320
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