A 33

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Cat.No. 6313 - A 33 | C19H18ClN3O2S | CAS No. 915082-52-9
说明: Potent and selective PDE4B inhibitor
化学名: 2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid
纯度: ≥98% (HPLC)
文献 (2)

生物活性 for A 33

A 33 is a potent and selective PDE4B inhibitor (IC50 = 15 nM); exhibits >100-fold selectivity for PDE4B over 4D. Regulates cAMP in inflammatory cells. Inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. Reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. Also exhibits antidepressant-like effects. Orally bioavailable.

技术数据 for A 33

分子量 387.88
公式 C19H18ClN3O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 915082-52-9
PubChem ID 15951010
Smiles CCC1=C(N=C(C2=CC=C(S2)Cl)N=C1NC3=CC=C(C=C3)CC(O)=O)C


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溶解性数据 for A 33

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 38.79 100

制备储备液 for A 33

以下数据基于产品分子量 387.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.89 mL 25.78 mL
5 mM 0.52 mL 2.58 mL 5.16 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for A 33


Naganuma et al (2009) Discovery of selective PDE4B inhibitors. Bioorg.Med.Chem.Lett. 19 3174 PMID: 19447034

Zhang et al (2017) Comparison of the pharmacological profiles of selective PDE4B and PDE4D inhibitors in the central nervous system. Sci.Rep. 7 40115 PMID: 28054669

Wilson et al (2017) Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury. PLoS One 12 e0178013 PMID: 28542295

If you know of a relevant reference for A 33, please let us know.



查看全部 Phosphodiesterase Inhibitors

关键词: A 33, A 33 supplier, A33, potent, selective, PDE4B, phosphodiesterase, inhibitors, inhibits, orally, bioavailable, anti-inflammatory, antidepressant, TBI, traumatic, brain, injury, Phosphodiesterases, 6313, Tocris Bioscience

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