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说明： Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker
化学名： N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide
纯度： ≥98% (HPLC)
生物活性 for A 1899
A 1899 is a potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) channel blocker (IC50 values are 7 nM and 70 nM for human TASK-1 and TASK-3 expressed in CHO cells, respectively). Displays >12.5-fold selectivity for TASK-1 and TASK-3 over other K+ channels (IC50 = 0.9 μM for K2P18.1/TRESK and >2 μM for all other channels tested). Binds within open channel pore.
化合物库 for A 1899
A 1899 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for A 1899
| 分子量 | 500.55 |
| 公式 | C30H26F2N2O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 498577-46-1 |
| PubChem ID | 9827303 |
| InChI Key | IXKPEYHRIVQTCU-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1)CC(NCC2=C(C3=C(C(NCC4=C(C=C(C=C4)F)F)=O)C=CC=C3)C=CC=C2)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for A 1899
参考文献 for A 1899
参考文献是支持产品生物活性的出版物。
Streit et al (2011) A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J.Biol.Chem. 286 13977 PMID: 21362619
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关键词: A 1899, A 1899 supplier, A1899, potassium, channel, two, pore, blockers, blocks, task1, task-1, task3, potent, Two-P, Potassium, Channels, 6972, Tocris Bioscience
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