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说明： Potent and selective positive allosteric modulator of M4 receptors; orally bioavailable and brain penetrant
化学名： 5-Amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
纯度： ≥98% (HPLC)
生物活性 for VU 0467485
VU 0467485 is a potent and selective positive allosteric modulator of M4 receptor; potentiates activity of ACh at M4 (EC50 values are 26.6 and 78.8 nM at rat and human M4 receptors, respectively). Exhibits selectivity for M4 over human and rat M1-3, 5, and a panel of 200 other pharmacological targets. Displays efficacy in a rat model of antipsychotic activity. Orally bioavailable and brain penetrant.
许可信息
Sold under license from Vanderbilt University.
技术数据 for VU 0467485
| 分子量 | 360.41 |
| 公式 | C17H17FN4O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1451994-10-7 |
| PubChem ID | 89777239 |
| InChI Key | VFNHDIWHQGVWLL-UHFFFAOYSA-N |
| Smiles | COC1=C(C=C(C=C1)CNC(C2=C(C3=C(C(C)=NN=C3S2)C)N)=O)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 0467485
参考文献 for VU 0467485
参考文献是支持产品生物活性的出版物。
Wood et al (2016) Discovery of VU0467485/AZ13713945: an M4 PAM evaluated as a preclinical candidate for the treatment of schizophrenia. ACS Med.Chem.Lett. 8 233 PMID: 28197318
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关键词: VU 0467485, VU 0467485 supplier, VU0467485, positive, allosteric, modulators, selective, acetycholine, muscarinic, receptors, M4, antipsychotic, orally, bioavailable, Receptors, 6932, Tocris Bioscience
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