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TC-E 5005

Cat. No. 4572 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4572 has been discontinued.

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说明： Potent and selective PDE10A inhibitor
化学名： 2-Methoxy-6,7-dimethyl-9-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for TC-E 5005

TC-E 5005 is a potent and selective PDE10A inhibitor (IC50 values are 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively and >5000 nM at PDE1B, 4A, 6, 8A and 9A). Reverses MK 801-induced hyperactivity in vivo.

技术数据 for TC-E 5005

分子量 270.33
公式 C15H18N4O
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 959705-64-7
PubChem ID 24802717
InChI Key YNADXFWEXJTQSZ-UHFFFAOYSA-N
Smiles CC2=NC1=CC=C(OC)N=C1N3C2=C(C)N=C3CCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TC-E 5005

参考文献是支持产品生物活性的出版物。

Hofgen et al (2010) Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J.Med.Chem. 53 4399 PMID: 20450197

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关键词: TC-E 5005, TC-E 5005 supplier, TC-E5005, PDE10A, inhibitors, inhibits, phosphodiesterase, 10A, potent, selective, Phosphodiesterases, 4572, Tocris Bioscience

篇 TC-E 5005 的引用文献

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TC-E 5005 的评论

平均评分: 4 (Based on 1 Review.)

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PDE inhibition assay in tissue culture.
By Anonymous on 01/04/2018
分析类型： In Vitro
种属： Human
细胞系/组织： Hela x fibroblast hybrid

Dosed product into cell culture media to final concentration of 10uM and at various time points up to 72h and isolated RNA from cells for downstream qPCR analysis to review effect of PDE inhibition on cell line phenotype.

Gentle warming of solution while resuspending in 45C water bath was very helpful in the process.