TC 14012

Pricing Availability   Qty
Cat.No. 4300 - TC 14012 | Arg-Arg-Nal-Cys-Tyr-Cit-Lys-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2 (Modifications: Disulfide bridge between 4 - 13, Cit-8 = D-Citrulline) | CAS No. 368874-34-4
说明: CXCR4 antagonist; ACKR3 (CXCR7) agonist
说明书
引用文献
评论
文献 (4)

生物活性 for TC 14012

TC 14012 is a CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).

技术数据 for TC 14012

分子量 2066.43
公式 C90H140N34O19S2
序列 RRACYXKXPYRXCR

(Modifications: Disulfide bridge between 4 - 13, Arg-14 = C-terminal amide, Ala-3 = 3-(2-naphthalenyllalanine), X-6 and X-12 = L-Citrulline, X-8 = D-Citrulline)

储存 Store at -20°C
CAS Number 368874-34-4
PubChem ID 90488928
InChI Key SGDDHDBBOJNZKY-UXNLHULBSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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溶解性数据 for TC 14012

溶解性 Soluble to 1 mg/ml in water

产品说明书 for TC 14012

分析证书/产品说明书
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参考文献 for TC 14012

参考文献是支持产品生物活性的出版物。

Tamamura et al (2003) Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org.Biomol.Chem. 1 3656 PMID: 14649896

Burger et al (2005) Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106 1824 PMID: 15905192

Gravel et al (2010) The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains. J.Biol.Chem. 285 37939 PMID: 20956518


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关键词: TC 14012, TC 14012 supplier, TC14012, cxcr4, antagonists, inverse, agonists, cxcr7, chemokines, Chemokine, CXC, Receptors, 4300, Tocris Bioscience

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