Pricing Availability   Qty
Cat.No. 6566 - STAD 2 | NH2-PEG3-CH2-CO-Lys-Lys-Leu-Ala-Lys-Phe-Leu-Val-Ser-[(S)-2-(4-pentenyl)alanine]-Ala-Leu-Lys-[(S)-2-(4-pentenyl)alanine]-Ala-Leu-Lys (double bond covalent bridge: X-10-X-14) | CAS No. 1542100-77-5
说明: AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable
文献 (1)

生物活性 for STAD 2

STAD 2 is an AKAP disruptor. Selectively binds PKA-RII subunit with high affinity (Kd = 6.2 nM) and blocks its interaction with AKAP. Cell permeable. Selectively permeable to malaria-infected red blood cells and displays antimalarial activity through a PKA-independent mechanism.

技术数据 for STAD 2

分子量 2096.68
公式 C102H182N24O22

(Modifications: Lys-1 = NH2-PEG3-CH2-CO-Lys, X = (S)-2-(4-pentenyl)alanine, X-10 and X-14 stapled together with a double bond)

储存 Store at -20°C
CAS Number 1542100-77-5
Smiles CC(C[C@@H](C(N[C@H](C(N)=O)CCCCN)=O)NC([C@@H](NC([C@@]1(CCC/C=C/CCC[C@](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(COCCOCCOCCN)=O)CCCCN)=O)CCCCN)=O)CC(C)C)=O)C)=O)CCCCN)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)=O)CO)=O)(C(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)CCCCN)=O)CC(C)C)=O)C)=O)C)C)=O)C)=O)C


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溶解性数据 for STAD 2

溶解性 Soluble to 1 mg/ml in 50% acetonitrile / water

参考文献 for STAD 2


Bendzunas et al (2018) Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg.Med.Chem. 26 1174 PMID: 29449124

Flaherty et al (2015) The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism. PLoS One 10 e0129239 PMID: 26010880

Wang et al (2014) Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem.Biol. 9 635 PMID: 24422448

If you know of a relevant reference for STAD 2, please let us know.


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关键词: STAD 2, STAD 2 supplier, STAD2, stapled, peptide, selective, AKAP, disruptors, disrupts, a-kinase, anchoring, proteins, RII, antimalarial, PKA, protein, kinase, A, A-kinase-anchoring, protiens, Antimalarials, Stapled, Peptides, 6566, Tocris Bioscience

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Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.