STAD 2

Pricing Availability   Qty
Cat.No. 6566 - STAD 2 | NH2-PEG3-CH2-CO-Lys-Lys-Leu-Ala-Lys-Phe-Leu-Val-Ser-[(S)-2-(4-pentenyl)alanine]-Ala-Leu-Lys-[(S)-2-(4-pentenyl)alanine]-Ala-Leu-Lys (double bond covalent bridge: X-10-X-14) | CAS No. 1542100-77-5
说明: AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable
说明书
引用文献
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生物活性 for STAD 2

STAD 2 is an AKAP disruptor. Selectively binds PKA-RII subunit with high affinity (Kd = 6.2 nM) and blocks its interaction with AKAP. Cell permeable. Selectively permeable to malaria-infected red blood cells and displays antimalarial activity through a PKA-independent mechanism.

技术数据 for STAD 2

分子量 2096.68
公式 C102H182N24O22
序列 KKLAKFLVSXALKXALK

(Modifications: Lys-1 = NH2-PEG3-CH2-CO-Lys, X = (S)-2-(4-pentenyl)alanine, X-10 and X-14 stapled together with a double bond)

储存 Store at -20°C
CAS Number 1542100-77-5
Smiles CC(C[C@@H](C(N[C@H](C(N)=O)CCCCN)=O)NC([C@@H](NC([C@@]1(CCC/C=C/CCC[C@](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(COCCOCCOCCN)=O)CCCCN)=O)CCCCN)=O)CC(C)C)=O)C)=O)CCCCN)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)=O)CO)=O)(C(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)CCCCN)=O)CC(C)C)=O)C)=O)C)C)=O)C)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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溶解性数据 for STAD 2

溶解性 Soluble to 1 mg/ml in 50% acetonitrile / water

参考文献 for STAD 2

参考文献是支持产品生物活性的出版物。

Bendzunas et al (2018) Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg.Med.Chem. 26 1174 PMID: 29449124

Flaherty et al (2015) The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism. PLoS One 10 e0129239 PMID: 26010880

Wang et al (2014) Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem.Biol. 9 635 PMID: 24422448


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关键词: STAD 2, STAD 2 supplier, STAD2, stapled, peptide, selective, AKAP, disruptors, disrupts, a-kinase, anchoring, proteins, RII, antimalarial, PKA, protein, kinase, A, A-kinase-anchoring, protiens, Antimalarials, Stapled, Peptides, 6566, Tocris Bioscience

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