Spermine NONOate

Name: Spermine NONOate
Brand: Tocris Bioscience
SKU: 1135

Cat. No. 1135 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1135 has been discontinued.

View all NO Donors / Precursors products.

说明： Slow NO releasing agent

化学名： N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl-1,3-propanediamine

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Spermine NONOate

A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC₅₀ = 6.2 μM for relaxation of rabbit aorta, and t_½ =39 min at 37°C, pH 7.4, aqueous solution).

许可信息

Sold with the permission of the NIH, US Patent 5,155,137

技术数据 for Spermine NONOate

分子量	262.35
公式	C₁₀H₂₆N₆O₂
储存	Desiccate at -20°C
CAS Number	136587-13-8
PubChem ID	5259
InChI Key	QPIOUFBAROSIAN-UHFFFAOYSA-N
Smiles	NCCCN(N(O)N=O)CCCCNCCCN

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Spermine NONOate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Spermine NONOate

参考文献是支持产品生物活性的出版物。

Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779 PMID: 10401570

Homer and Wanstall (1998) In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur.J.Pharmacol. 356 49 PMID: 9761423

Maragos et al (1991) Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J.Med.Chem. 34 3242 PMID: 1956043

Ramamurthi and Lewis (1997) Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem.Res.Toxicol. 10 408 PMID: 9114977

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关键词: Spermine NONOate, Spermine NONOate supplier, Slow, NO, releasing, agent, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, /, 1135, Tocris Bioscience

1 篇 Spermine NONOate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Spermine NONOate 的部分引用包括：

Russell et al (2013) Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range. FEBS J 280 6070 PMID: 24034856