Sotalol hydrochloride

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Cat.No. 0952 - Sotalol hydrochloride | C12H20N2O3S.HCl | CAS No. 959-24-0
说明: β antagonist
化学名: N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride
纯度: ≥99% (HPLC)
说明书
引用文献 (3)
评论
文献 (4)

生物活性 for Sotalol hydrochloride

Sotalol hydrochloride is a relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity.

技术数据 for Sotalol hydrochloride

分子量 308.82
公式 C12H20N2O3S.HCl
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 959-24-0
PubChem ID 66245
InChI Key VIDRYROWYFWGSY-UHFFFAOYSA-N
Smiles Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sotalol hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 15.44 50

制备储备液 for Sotalol hydrochloride

以下数据基于产品分子量 308.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 6.48 mL 32.38 mL 64.76 mL
2.5 mM 1.3 mL 6.48 mL 12.95 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
25 mM 0.13 mL 0.65 mL 1.3 mL

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产品说明书 for Sotalol hydrochloride

分析证书/产品说明书
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参考文献 for Sotalol hydrochloride

参考文献是支持产品生物活性的出版物。

Claudel and Touboul (1995) Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'. Pacing Clin.Electrophysiol. 18 451 PMID: 7770366

Fiset et al (1997) Block of Iks by the diuretic agent indap. modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J.Pharmacol.Exp.Ther. 283 148 PMID: 9336319

Uloth et al (1966) Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines. J.Med.Chem. 9 88 PMID: 6006227

Merck Index 12 8876


If you know of a relevant reference for Sotalol hydrochloride, please let us know.

关键词: Sotalol hydrochloride, Sotalol hydrochloride supplier, β-adrenoceptor, beta-adrenoceptors, b-adrenergic, β-adrenergic, beta-adrenergic, b-adrenoceptors, antagonists, Receptors, Non-Selective, Non-selective, Adrenergic, Beta, 0952, Tocris Bioscience

3 篇 Sotalol hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Sotalol hydrochloride 的部分引用包括:

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572

McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Neurosci 329 350 PMID: 19144685


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