Sotalol hydrochloride

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Cat.No. 0952 - Sotalol hydrochloride | C12H20N2O3S.HCl | CAS No. 959-24-0
说明: β antagonist
化学名: N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride
纯度: ≥99% (HPLC)
引用文献 (3)
文献 (4)

生物活性 for Sotalol hydrochloride

Sotalol hydrochloride is a relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity.

技术数据 for Sotalol hydrochloride

分子量 308.82
公式 C12H20N2O3S.HCl
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 959-24-0
PubChem ID 66245
Smiles Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sotalol hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
water 15.44 50

制备储备液 for Sotalol hydrochloride

以下数据基于产品分子量 308.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 6.48 mL 32.38 mL 64.76 mL
2.5 mM 1.3 mL 6.48 mL 12.95 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
25 mM 0.13 mL 0.65 mL 1.3 mL

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产品说明书 for Sotalol hydrochloride


参考文献 for Sotalol hydrochloride


Claudel and Touboul (1995) Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'. Pacing Clin.Electrophysiol. 18 451 PMID: 7770366

Fiset et al (1997) Block of Iks by the diuretic agent indap. modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J.Pharmacol.Exp.Ther. 283 148 PMID: 9336319

Uloth et al (1966) Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines. J.Med.Chem. 9 88 PMID: 6006227

Merck Index 12 8876

If you know of a relevant reference for Sotalol hydrochloride, please let us know.

关键词: Sotalol hydrochloride, Sotalol hydrochloride supplier, β-adrenoceptor, beta-adrenoceptors, b-adrenergic, β-adrenergic, beta-adrenergic, b-adrenoceptors, antagonists, Receptors, Non-Selective, Non-selective, Adrenergic, Beta, 0952, Tocris Bioscience

3 篇 Sotalol hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Sotalol hydrochloride 的部分引用包括:

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572

McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Neurosci 329 350 PMID: 19144685

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