SNAP 398299

Discontinued Product

5426 has been discontinued.

View all Galanin Receptors products.
说明: Potent and selective GAL3 antagonist
化学名: 1,3-Dihydro-1-[3-[2-(1-pyrrolidinyl)ethoxy]phenyl]-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one
纯度: ≥97% (HPLC)
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生物活性 for SNAP 398299

Potent and selective GAL3 antagonist (Ki = 5 nM). Exhibits greater than 100-fold selectively for GAL3 over GAL1, GAL2, adrenergic α1a and dopamine D5 receptors. Anxiolytic- and antidepressant-like effects in vivo.

技术数据 for SNAP 398299

分子量 479.49
公式 C27H24F3N3O2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 903878-06-8
PubChem ID 11698643
InChI Key HXCJZIBJTFITNI-UHFFFAOYSA-N
Smiles O=C3/C(C2=CC=CC=C2N3C4=CC(OCCN5CCCC5)=CC=C4)=N/C1=CC=CC(C(F)(F)F)=C1

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Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SNAP 398299

参考文献是支持产品生物活性的出版物。

Swanson et al (2005) Anxiolytic- and antidepressant-like profiles of the galanin-3 (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc.Natl.Acad.Sci.U.S.A 102 17489 PMID: 16287967

Konkel et al (2006) Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility. Bioorg.Med.Chem.Lett. 16 3950 PMID: 16730981

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关键词: SNAP 398299, SNAP 398299 supplier, SNAP398299, high, affinity, selective, gal3, antagonists, antagonism, galanin, Galanin, Receptors, 5426, Tocris Bioscience

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