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Submit ReviewSL 0101-1
说明： Selective ribosomal S6 kinase (RSK) inhibitor
化学名： 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one
纯度： ≥95% (HPLC)
生物活性 for SL 0101-1
SL 0101-1 is a selective inhibitor of ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.
技术数据 for SL 0101-1
| 分子量 | 516.46 |
| 公式 | C25H24O12 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 77307-50-7 |
| PubChem ID | 14825856 |
| InChI Key | SXOZSDJHGMAEGZ-UHFFFAOYSA-N |
| Smiles | O=C1C3=C(C=C(O)C=C3O)OC(C4=CC=C(O)C=C4)=C1OC2C(O)C(OC(C)=O)C(OC(C)=O)C(C)O2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SL 0101-1
参考文献 for SL 0101-1
参考文献是支持产品生物活性的出版物。
Smith et al (2005) Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 65 1027 PMID: 15705904
Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297 PMID: 17850214
Godeny and Sayeski (2006) ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. Am.J.Cell.Physiol. 291 1308
Saha et al (2012) RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. Biochem.J. 447 159 PMID: 22827337
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关键词: SL 0101-1, SL 0101-1 supplier, Selective, p90, ribosomal, S6, kinases, RSK, inhibitors, inhibits, SL0101-1, 2250, Tocris Bioscience
7 篇 SL 0101-1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SL 0101-1 的部分引用包括：
Gawecka et al (2012) RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J Biol Chem 287 43424 PMID: 23118220
Li et al (2012) Involvement of polo-like kinase 1 (Plk1) in mitotic arrest by inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase-ribosomal S6 kinase 1 (MEK-ERK-RSK1) cascade. PLoS One 287 15923 PMID: 22427657
Al-Ejeh et al (2014) Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. J Biol Chem 5 3145 PMID: 24762669
Kroczynska et al (2011) Regulatory effects of ribosomal S6 kinase 1 (RSK1) in IFNλ signaling. J Biol Chem 286 1147 PMID: 21075852
Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600
Gawecka et al (2012) PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma. Int J Cancer 131 1556 PMID: 22213050
Roselli et al (2009) Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. PLoS One 4 e6011 PMID: 19547699
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