SKA 31

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Cat.No. 3670 - SKA 31 | C11H8N2S | CAS No. 40172-65-4
说明: KCa3.1 (IK) and KCa2 (SK) channel activator
化学名: Naphtho[1,2-d]thiazol-2-ylamine
纯度: ≥99% (HPLC)
评论 (1)
文献 (2)

生物活性 for SKA 31

SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

化合物库 for SKA 31

SKA 31 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SKA 31

分子量 200.26
公式 C11H8N2S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 40172-65-4
PubChem ID 94880
Smiles NC3=NC2=C(S3)C=CC1=CC=CC=C12


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溶解性数据 for SKA 31

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 20.03 100
ethanol 20.03 100

制备储备液 for SKA 31

以下数据基于产品分子量 200.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.99 mL 24.97 mL 49.94 mL
5 mM 1 mL 4.99 mL 9.99 mL
10 mM 0.5 mL 2.5 mL 4.99 mL
50 mM 0.1 mL 0.5 mL 1 mL

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参考文献 for SKA 31


Sankaranarayanan et al (2009) Naphtho[1,2-d]thaizol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol.Pharmacol. 75 281 PMID: 18955585

Brahler et al (2009) Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 119 2323 PMID: 19380617

If you know of a relevant reference for SKA 31, please let us know.

关键词: SKA 31, SKA 31 supplier, Activators, KCa3.1, KCa2.1, KCa2.2, Ca2+-activated, potassium, K+, channels, SK1, SK2, small, conductance, SKA31, Ca2+-Activated, Potassium, Channels, 3670, Tocris Bioscience

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SKA 31 的评论

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SKA 31 is a great channel activator and works well on biological lab conditions.
By Anonymous on 10/13/2018
分析类型: In Vitro
种属: Human

Great product for studies on Kca channel opening as a measure to compare between other activators. Would use again and suggest to others.

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