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说明： PDE3 inhibitor
化学名： N-Cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
纯度： ≥99% (HPLC)
生物活性 for Siguazodan
Siguazodan is a phosphodiesterase inhibitor, selective for PDE3 (IC50 = 117 nM).
技术数据 for Siguazodan
| 分子量 | 284.32 |
| 公式 | C14H16N6O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 115344-47-3 |
| PubChem ID | 72124 |
| InChI Key | NUHPODZZKHQQET-UHFFFAOYSA-N |
| Smiles | CN\C(NC#N)=N/C1=CC=C(C=C1)C1=NNC(=O)CC1C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Siguazodan
参考文献 for Siguazodan
参考文献是支持产品生物活性的出版物。
Freitag et al (1998) Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from trachea of newborn rabbits. Eur.J.Pharmacol. 354 67 PMID: 9726632
Tang et al (1994) Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 268 105 PMID: 7925608
Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185
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关键词: Siguazodan, Siguazodan supplier, PDE3, inhibitors, inhibits, Phosphodiesterases, 1148, Tocris Bioscience
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