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(R)-DPN

Cat. No. 4494 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4494 has been discontinued.

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说明： Enantiomer of DPN (Cat. No. 1494)
化学名： (R)-2,3-bis(4-Hydroxyphenyl)-propionitrile
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for (R)-DPN

(R)-DPN is an enantiomer of DPN (Cat. No. 1494). Displays higher affinity for estrogen receptor (ER) β over ERα (Ki values are 1.82 and 147 nM respectively).

技术数据 for (R)-DPN

分子量 239.27
公式 C15H13NO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 524047-78-7
PubChem ID 6604873
InChI Key GHZHWDWADLAOIQ-ZDUSSCGKSA-N
Smiles OC(C=C2)=CC=C2C[C@@H](C#N)C1=CC=C(O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for (R)-DPN

参考文献是支持产品生物活性的出版物。

Weiser et al (2009) Estrogen receptor-β agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress. Endocrinology 150 1817 PMID: 19074580

Carroll et al (2011) Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J.Med.Chem. 55 528 PMID: 22122563

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关键词: (R)-DPN, (R)-DPN supplier, enantiomer, DPN, diarylpropionitrile, estrogen, receptors, ERbeta, ERb, ERβ, Estrogen, and, Related, Receptors, 4494, Tocris Bioscience

1 篇 (R)-DPN 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (R)-DPN 的部分引用包括：

Murata et al (2014) Rat uterine oxyt. receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors. Mol Cell Biol 60 55 PMID: 24334513

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Pathways for (R)-DPN

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.