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Submit ReviewPU 02
说明： Negative allosteric modulator of 5-HT3 receptors
化学名： 6-[(1-Naphthalenylmethyl)thio]-9H-purine
纯度： ≥97% (HPLC)
生物活性 for PU 02
PU 02 is a negative allosteric modulator of 5-HT3 receptors (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively).
技术数据 for PU 02
| 分子量 | 292.36 |
| 公式 | C16H12N4S |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 313984-77-9 |
| PubChem ID | 720937 |
| InChI Key | BGMSTNYJYPSLHN-UHFFFAOYSA-N |
| Smiles | C12=NC=NC(SCC3=C(C=CC=C4)C4=CC=C3)=C1NC=N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PU 02
参考文献 for PU 02
参考文献是支持产品生物活性的出版物。
Trattnig et al (2012) Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J.Biol.Chem. 287 25241 PMID: 22589534
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关键词: PU 02, PU 02 supplier, PU02, negative, allosteric, modulators, NAMs, 5-HT3, receptors, serotonergics, Receptors, 4700, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.