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Submit ReviewPKUMDL WQ 2101
说明： Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
化学名： 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
纯度： ≥98% (HPLC)
生物活性 for PKUMDL WQ 2101
PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.
技术数据 for PKUMDL WQ 2101
| 分子量 | 317.25 |
| 公式 | C14H11N3O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 304481-72-9 |
| PubChem ID | 6741780 |
| InChI Key | RABUUVVWWJCYEN-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=C(C(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PKUMDL WQ 2101
参考文献 for PKUMDL WQ 2101
参考文献是支持产品生物活性的出版物。
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046
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关键词: PKUMDL WQ 2101, PKUMDL WQ 2101 supplier, PKUMDLWQ2101, Phosphoglycerate, dehydrogenase, PHGDH, allosteric, inhibitor, serine, biosynthesis, negative, modulator, NAM, Other, Dehydrogenases, 6580, Tocris Bioscience
1 篇 PKUMDL WQ 2101 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PKUMDL WQ 2101 的部分引用包括：
John M et al (2022) Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nat Commun 13 2698 PMID: 35577785
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