PKI 14-22 amide, myristoylated

Pricing Availability   Qty
Cat.No. 2546 - PKI 14-22 amide, myristoylated | Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 | CAS No. 201422-03-9
说明: Cell-permeable protein kinase A inhibitor
别名: Protein kinase inhibitor-(14-22)-amide, myristoylated
纯度: ≥95% (HPLC)
引用文献 (16)
文献 (3)

生物活性 for PKI 14-22 amide, myristoylated

PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

技术数据 for PKI 14-22 amide, myristoylated

分子量 1209.5
公式 C53H100N20O12

(Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)

储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 201422-03-9
PubChem ID 71312213
Smiles [H]N(CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)C(=O)CCCCCCCCCCCCC


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PKI 14-22 amide, myristoylated

溶解性 Soluble to 1 mg/ml in DMSO

产品说明书 for PKI 14-22 amide, myristoylated


参考文献 for PKI 14-22 amide, myristoylated


Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802 PMID: 2722799

Zheng et al (2000) Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 275 31747 PMID: 10829013

Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197 PMID: 12947318

If you know of a relevant reference for PKI 14-22 amide, myristoylated, please let us know.


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关键词: PKI 14-22 amide, myristoylated, PKI 14-22 amide, myristoylated supplier, Cell-permeable, protein, kinases, A, inhibitors, inhibits, Cell, permeable, PKA, PKI14-22, amide, myristoylated, Protein, kinase, inhibitor-(14-22)-amide,, Kinase, 2546, Tocris Bioscience

16 篇 PKI 14-22 amide, myristoylated 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PKI 14-22 amide, myristoylated 的部分引用包括:

Hamnett et al (2019) Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling. Nat Commun 10 542 PMID: 30710088

Hashimotodani et al (2017) LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron 95 928 PMID: 28817805

Muñoz-Llancao et al (2015) Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J Exp Med 35 11315 PMID: 26269639

Watson et al (2015) Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Biol Chem 212 1021 PMID: 26101266

Singh et al (2015) The Orphan G Protein-Coupled Receptor Gpr175 (TPRA40) Enhances Hedgehog Signaling by Modulating cAMP Levels. J Biol Chem NULL PMID: 26451044

Okumura et al (2014) Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase. PLoS One 9 e100559 PMID: 24945349

Adelfinger et al (2014) GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochem Pharmacol 91 369 PMID: 25065880

Maddugoda et al (2011) cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization. Cell Host Microbe 10 464 PMID: 22100162

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600

Stival et al (2018) Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. J Biol Chem 293 9435 PMID: 29700114

Liu et al (2008) Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery. Invest Ophthalmol Vis Sci 49 772 PMID: 18235027

Al-Amily et al (2019) The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent. Pflugers Arch 471 633 PMID: 30767071

Caiati et al (2013) PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. J Neurosci 33 2973 PMID: 23407955

Jakobsen et al (2019) Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function. J Neurosci Res 97 1018 PMID: 31172581

Jantarajit et al (2017) CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels. Am J Physiol Cell Physiol 313 C118 PMID: 28490422

Tseng et al (2010) PKA-induced receptor activator of NF-κB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification. Autophagy 285 29925 PMID: 20663885

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