PKC β pseudosubstrate

Name: PKC β pseudosubstrate
Brand: Tocris Bioscience
SKU: 1792

Cat. No. 1792 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1792 has been discontinued.

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说明： Selective cell-permeable PKC inhibitor peptide (attached to vector)

别名： Protein kinase C beta pseudosubstrate

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for PKC β pseudosubstrate

PKC β pseudosubstrate is a selective cell-permeable peptide inhibitor of protein kinase C (IC₅₀ ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.

技术数据 for PKC β pseudosubstrate

分子量	3994.84
公式	C₁₇₇H₂₉₄N₆₂O₃₈S₃
序列	CRQIKIWFQNRRMKWKK CRFARKGALRQKNV* (Modifications: Disulfide bridge between 17 -1*)
储存	Store at -20°C
CAS Number	172308-76-8
PubChem ID	90488712
InChI Key	KIWJPYSSLFMLBZ-OSCDWKIESA-N
Smiles	[H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PKC β pseudosubstrate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PKC β pseudosubstrate

参考文献是支持产品生物活性的出版物。

Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 269 10444 PMID: 8144628

House and Kemp (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238 1726 PMID: 3686012

Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID: 7472470

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关键词: PKC b pseudosubstrate, PKC b pseudosubstrate supplier, Selective, cell-permeable, PKC, inhibitors, inhibits, Protein, Kinases, C, beta, pseudosubstrate, PKCb, kinase, Kinase, 1792, Tocris Bioscience

篇 PKC β pseudosubstrate 的引用文献

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目前没有 PKC β pseudosubstrate 的引用文献。