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Submit ReviewPinacidil
Discontinued Product
1503 has been discontinued.
View all Inward Rectifier Potassium (K<sub>ir</sub>) Channels products.
说明： K+ channel opener. Activates KATP channels
化学名： N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine
纯度： ≥98% (HPLC)
生物活性 for Pinacidil
K+ channel opener and vasodilator. Activates KATP channels (IC50 for relaxation of coronary arteries = 1.26 μM). Clinically used antihypertensive agent.
技术数据 for Pinacidil
| 分子量 | 245.33 |
| 公式 | C13H19N5 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 60560-33-0 |
| Smiles | CC(N\C(NC1=CC=NC=C1)=N/C#N)C(C)(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Pinacidil
参考文献 for Pinacidil
参考文献是支持产品生物活性的出版物。
Gollasch et al (1995) Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J.Pharmacol.Exp.Ther. 275 681 PMID: 7473155
Kimura et al (1988) Effects of an antihypertensive vasodilator, pinacidil, on regional blood flow in conscious spontaneously hypertensive rats. J.Pharmacobiodyn. 11 430 PMID: 3171884
Petersen (1978) Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines. J.Med.Chem. 21 773 PMID: 691003
关键词: Pinacidil, Pinacidil supplier, Inward, rectifier, Potassium, Channels, 1503, Tocris Bioscience
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