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说明： Potent hepatoselective glucokinase activator
化学名： 6-[[(2S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for PF 04991532
PF 04991532 is a potent hepatoselective glucokinase activator (EC50 = 90 nM). Exhibits >50-fold liver to pancreas ratio of tissue distribution. Reduces fasting and postprandial glucose levels with no hypoglycemia in a rat diabetes model.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 04991532
| 分子量 | 396.36 |
| 公式 | C18H19F3N4O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1215197-37-7 |
| PubChem ID | 46181428 |
| InChI Key | GKMLFBRLRVQVJO-ZDUSSCGKSA-N |
| Smiles | O=C(NC1=CC=C(C(O)=O)C=N1)[C@@H](N2C=NC(C(F)(F)F)=C2)CC3CCCC3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 04991532
参考文献 for PF 04991532
参考文献是支持产品生物活性的出版物。
Pfefferkorn et al (2012) Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. J.Med.Chem. 55 1318 PMID: 22196621
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关键词: PF 04991532, PF 04991532 supplier, PF04991532, glucokinase, activators, activates, potent, antidiabetic, Hexokinases, Enzyme, Substrates, /, Activators, 6345, Tocris Bioscience
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