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PF 04937319

Cat. No. 6049 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6049 has been discontinued.

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说明： Glucokinase partial activator
化学名： N,N-Dimethyl-5-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-2-pyrimidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for PF 04937319

PF 04937319 is a glucokinase partial activator (EC50 = 174 nM). Enhances glucose-stimulated insulin secretion in islet cell cultures and translocation of glucokinase from the nucleus to the cytoplasm in hepatocytes in vitro. Reduces post-prandial plasma glucose levels in an oral glucose tolerance test in rats.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for PF 04937319

分子量 432.43
公式 C22H20N6O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1245603-92-2
PubChem ID 46916694
InChI Key MASKQITXHVYVFL-UHFFFAOYSA-N
Smiles CC1=CC2=C(OC3=CN=C(C(N(C)C)=O)N=C3)C=C(C(NC4=CN=C(C)C=N4)=O)C=C2O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PF 04937319

参考文献是支持产品生物活性的出版物。

Pfefferkorn et al (2011) Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 di Med.Chem.Commun., 2 828

Pettersen et al (2014) The relationship of glucokinase activator-induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies. Toxicol. Pathol. 42 696 PMID: 24771080

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关键词: PF 04937319, PF 04937319 supplier, PF04937319, Glucokinase, partial, activators, activates, type, 2, diabetes, Hexokinases, 6049, Tocris Bioscience

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